Alios Scientific Publications

Solid-phase synthesis of 5'-triphosphate 2'-5'-oligoadenylates analogs with 3'-O-biolabile groups and their evaluation as RNase L activators and antiviral drugs
Bioorganic & Medicinal Chemistry, 2013, 21 (17), pp 5461
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2,2-Disubstituted 4-Acylthio-3-oxobutyl Groups as Esterase- and Thermolabile Protecting Groups of Phosphodiesters
J. Org. Chem., 2013, 78 (3), pp 950-959 DOI: 10.1021/jo302421u
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Biodegradable protections for nucleoside 5'-monophosphates: comparative study on the removal of O-acetyl and O-acetyloxymethyl protected 3-hydroxy-2,2-bis(ethoxycarbonyl)propyl groups
J Org Chem. 2009, 74 (14), pp4992-5001. DOI: 10.1021/jo9005987
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Chemical and enzymatic stability of amino acid derived phosphoramidates of antiviral nucleoside 5'-monophosphates bearing a biodegradable protecting group
Org Biomol Chem. 2010 May 7;8(9):2131-41. doi: 10.1039/b924321f
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Synthesis and enzymatic deprotection of biodegradably protected dinucleoside-2',5'-monophosphates: 3-(acetyloxy)-2,2-bis(ethoxycarbonyl)propyl phosphoesters of 3'-O-(acyloxymethyl)adenylyl-2',5'-adenosines
Chem Biodivers. 2011 Feb;8(2):266-86. doi: 10.1002/cbdv.201000288.
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Synthesis and Enzymatic Deprotection of Fully Protected 2'-5' Oligoadenylates (2-5A): Towards a Prodrug Strategy for Short 2-5A
Chemistry & Biodiversity, Volume 9, Issue 4, pages 669-688, April 2012
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Synthesis of 3',5'-Cyclic Phosphate and Thiophosphate Esters of 2'-C-Methyl Ribonucleosides
Helvetica Chimica Acta, Volume 95, Issue 9, pages 1512-1520, September 2012
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Hepatitis C Virus and Its Inhibitors: The Polymerase as a Target for Nucleoside and Nucleotide Analogs
Chapter 3: “Cancer-Causing Viruses and Their Inhibitors” May 29, 2014 by CRC Press, Editor Satya Prakash Gupta
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The Ambiguous Base-Pairing and High Substrate Efficiency of T-705 (Favipiravir) Ribofuranosyl 5'-Triphosphate towards Influenza A Virus Polymerase
PLoS ONE 8(7): e68347. doi: 10.1371/journal.pone.0068347
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Assays for RNA synthesis and replication by the hepatitis C virus
Frontiers in Biology 2012, 7(3), pp 233-245
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Endonuclease substrate selectivity characterized with full-length PA of influenza A virus polymerase
Virology 2012, 433(1), pp 27-34.
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Biochemical Study of the Comparative Inhibition of Hepatitis C Virus RNA Polymerase by VX-222 and Filibuvir
Antimicrobial Agents and Chemotherapy 2012, 56 (2), pp 830-837
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