Scientific Publications

Biodegradable protections for nucleoside 5'-monophosphates: comparative study on the removal of O-acetyl and O-acetyloxymethyl protected 3-hydroxy-2,2-bis(ethoxycarbonyl)propyl groups.

Ora M, Taherpour S, Linna R, Leisvuori A, Hietamäki E, Poijärvi-Virta P, Beigelman L, Lönnberg H.
J Org Chem. 2009 Jul 17;74(14):4992-5001.
Publication

 

Chemical and enzymatic stability of amino acid derived phosphoramidates of antiviral nucleoside 5'-monophosphates bearing a biodegradable protecting group.

Leisvuori A, Aiba Y, Lönnberg T, Poijärvi-Virta P, Blatt L, Beigelman L, Lönnberg H.
Org Biomol Chem. 2010 May 7;8(9):2131-41.
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Synthesis and Enzymatic Deprotection of Biodegradably Protected Dinucleoside-2',5'-monophosphates: 3-(Acetyloxy)-2,2-bis(ethoxycarbonyl)propyl Phosphoesters of 3'-O-(Acyloxymethyl)adenylyl-2',5'-adenosines.

Kiuru E, Ora M, Beigelman L, Blatt L, Lönnberg H.
Chem Biodivers. 2011 Feb;8(2):266-86.
Publication