Alios BioPharma, Inc. is a biotechnology company located in San Francisco, California that is developing novel medicines that treat diseases in virology by activating pathways in the innate immune system. Alios is pursuing the development of both protein and small molecule therapeutics, each addressing major commercial market opportunities.

Alios is discovering and developing novel antiviral agents based on three platform technologies including: small molecule activators of innate immunity antiviral pathways (RNase L activation), phosphate protected nucleotide prodrugs, and glycoprotein-engineering of interferons (Glycoferon). This complementary group of platform technologies has the potential to generate a number of distinct therapeutic products to treat a variety of serious viral infections such as chronic hepatitis B and C, HIV infection, respiratory viruses (e.g. pandemic influenza) and emerging viral diseases (e.g. SARS).

At Alios, our science is the key to our success, and to improving patients' quality of life. Our pipeline of developing novel compounds and investigative therapies reflects our commitment to bring innovative products to patients with unmet needs in the areas of virology.

Responsibilities

Associate Director/Director, Assay Development Biochemistry

Lead Assay development and mechanistic Biochemistry efforts in several programs while staying active in the laboratory.

Manage external biochemistry projects at contract research organization(s).

Requirements

Ph.D. in relevant scientific discipline

10+ years of biochemical assays development with applications for drug discovery in the pharmaceutical/biotech industry.

Strong knowledge of enzyme kinetics and hands –on expertise in development of mechanism of action based inhibitors.

Demonstrated expertise in the field of structure based drug design as applied to viral polymerases is a strong plus.

Strong record of patent applications and scientific publications.

Self-starter, powerful innovator and energetic, personable scientist who is able to work collaboratively across different functional areas.